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Biophys. Acta, 159, 451 TIPTON, K. F. (1968c). Eur. J. , 5, 316 TIPTON, K. F. (1969). Biochem. , 18, 2559 TIPTON, K. F. & SPIRES, I. P. C. (1968). Biochem. , 17,2137 YouDIM, M. B. , CoLLINS, G. G. S. & SANDLER, M. (1969). , 223, 626 YoUDIM, M. B. H. & SouRKES, T. L. (1966). Can. J. , 44, 1397 ZELLER, E. A. (1951). In The Enzymes, vol. 2, Part 1, p. 536, ed. Sumner, J. B. , New York: Academic Press ZELLER, E. , BLANKSMA, L. , BURKARD, w. , PACHA, w. L. & LAZANAS, J. C. (1959). Ann. Y. Acad. , 80, 583.
Manning and Dr. , 1969). In these studies, Lmethionine sulphoximine phosphate was obtained from the enzyme after HaC N "'s/ o·,... / I c c /I"' c c c /j"' ,//'·... / .. ·'/'· .. "' / NHa c 0 NHa c 0 s "' 0 0 R FIG. 13. L-Methionine-S-sulphoximine and L-methionine-R-sulphoximine. Glutamine Synthetase Inhibition 55 it had been inhibited by incubation with L-methionine-SR-sulphoximine, ATP and magnesium ions. It was converted to the a-N-L-leucyl derivative and examined chromatographically by the procedure of Manning & Moore (1968) which enables the diastereoisomers of a-N-L-leucyl-L-methionineSR-sulphoximine phosphate to be separated.
J. Neuroi. Neurosurg. , GEY, K. F. & ZELLER, P. (1960). Progr. , 2, 417 SMITH, T. , WEISSBACH, H. & UDENFRIEND, S. (1963). Biochemistry, 2, 746 SOURKES, T. L. (1968). Adv. , 6A, 61 TIPTON, K. F. (1968a). Eur. J. , 4, 103 TIPTON, K. F. (1968b). Biochim. biophys. Acta, 159, 451 TIPTON, K. F. (1968c). Eur. J. , 5, 316 TIPTON, K. F. (1969). Biochem. , 18, 2559 TIPTON, K. F. & SPIRES, I. P. C. (1968). Biochem. , 17,2137 YouDIM, M. B. , CoLLINS, G. G. S. & SANDLER, M. (1969). , 223, 626 YoUDIM, M. B.
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