By K. Thapar, K. Kovacs, E. R. Laws (auth.), L. Symon, L. Calliauw, F. Cohadon, V. V. Dolenc, J. Lobo Antunes, H. Nornes, J. D. Pickard, H.-J. Reulen, A. J. Strong, N. de Tribolet (eds.)

ISBN-10: 3709168988

ISBN-13: 9783709168981

ISBN-10: 3709174287

ISBN-13: 9783709174289

As an addition to the eu postgraduate education procedure for younger neurosurgeons we started to post in 1974 this sequence of Advances and Technical criteria in Neurosurgery which was once later subsidized by way of the eu organization of Neurosurgical Societies. This sequence used to be fust mentioned in 1972 at a mixed assembly of the Italian and German Neurosurgical Societies in Taormina, the founding fathers of the sequence being Jean Brihaye, Bernard Pertuiset, Fritz Loew and Hugo KrayenbUhl. therefore have been verified the rules of eu co­ operation that have been born from the ecu spirit, flourished within the ecu organization, and feature all through been linked to this sequence. the truth that the English language is definitely so as to turning into the overseas medium at eu clinical meetings is a brilliant asset by way of mutual knowing. for that reason we've determined to submit all contributions in English, whatever the local language of the authors. All contributions are submitted to the whole editorial board earlier than publi­ cation of any quantity. Our sequence isn't really meant to compete with the guides of unique medical papers in different neurosurgical journals. Our goal is, fairly, to provide fields of neurosurgery and comparable components within which vital contemporary advances were made. The contributions are written by means of experts within the given fields and represent the fust a part of every one volume.

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Proliferation Markers and LaboratOlY Evaluation of Pituitary Tumor Aggressiveness Given the poor correlation which exists between the histopathology and aggressiveness of pituitary adenomas, the reliable prediction of their clinical behavior has proved to be one of the most inscrutable aspects of pituitary tumor biology. Accordingly, a number of contemporary strategies have been applied to the problem of assessing the proliferative potential of pituitary adenomas. Although many ofthese are still of research interest only, they are gradually reaching levels of clinical applicability.

1988). The most recent strategy for identifying differences in biological behavior among pituitary adenomas centers on the search for specific genomic alterations which could serve as markers of tumor aggressiveness. The subject of genomic alterations and pituitary tumorigenesis is discussed fully below, however, a few points merit discussion here. Of the genomic alterations screened for among pituitary adenomas and carcinomas, several have been preliminarily correlated with tumor aggressiveness (Fig.

1987), neuron-specific enolase (Asa et al. 1988), chromogranin (Lloyd et al. 1985), synaptophysin (Stefaneanu et al. 1988), galanin (Vrontakis et al. 1990) vasoactive-intestinal peptide (Hsu et al. 1989), S-100 protein (Marin et al. 1992), ubiquitin (Marin et al. 1986). Again, these findings have been 26 K. THAPAR et at. primarily of scientific and/or physiologic interest; none of these markers has proven prognostic ally or practically informative with respect to pituitary adenoma behavior. In recent years, several workers have studied pituitary adenomas with flow cytometry.

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