By S. Rumelt

ISBN-10: 9535102486

ISBN-13: 9789535102489

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The intact epithelium not only offers a smooth and clear optical surface, but also provides corneal barrier function. This property protects the underlying stroma from swelling and pathogenic invasion. Should such protection become compromised by ocular surface diseases, outcomes can range from mild symptoms, such as irritation, photophobia, to severe consequences including corneal opacity, ulceration and even perforation. TRP Transient Receptor Potential (TRP) Channels in the Eye 39 channel functions have been indicated to associate with maintaining corneal sensation and integrity.

Functional importances of TRP isotypes expressed in different ocular tissues are multi-faceted. Their activation is essential for retaining corneal deturgescence and clarity, mediating aqueous humor outflow through trabecular meshwork and ciliary body as well as inducing light sensation in retina. Mutation of TRP channels is associated with ocular pathological phenotypes either due to loss of its homeostatic role or over-activation of its function. The realization of the importance of TRP channel has prompted much research effort to investigate novel strategies for regulating TRP channels function in a number of ocular diseases.

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